Zaklina Kovacevic Selected Research

Thiosemicarbazones

10/2020	Thiosemicarbazones suppress expression of the c-Met oncogene by mechanisms involving lysosomal degradation and intracellular shedding.
1/2020	Overcoming tamoxifen resistance in oestrogen receptor-positive breast cancer using the novel thiosemicarbazone anti-cancer agent, DpC.
1/2020	Pharmacological targeting and the diverse functions of the metastasis suppressor, NDRG1, in cancer.
10/2019	Synthesis, Characterization, and in Vitro Anticancer Activity of Copper and Zinc Bis(Thiosemicarbazone) Complexes.
1/2019	Exploiting Cancer Metal Metabolism using Anti-Cancer Metal- Binding Agents.
1/2019	The metastasis suppressor, NDRG1, attenuates oncogenic TGF-β and NF-κB signaling to enhance membrane E-cadherin expression in pancreatic cancer cells.
1/2019	The metastasis suppressor NDRG1 down-regulates the epidermal growth factor receptor via a lysosomal mechanism by up-regulating mitogen-inducible gene 6.
1/2017	Novel Thiosemicarbazones Inhibit Lysine-Rich Carcinoembryonic Antigen-Related Cell Adhesion Molecule 1 (CEACAM1) Coisolated (LYRIC) and the LYRIC-Induced Epithelial-Mesenchymal Transition via Upregulation of N-Myc Downstream-Regulated Gene 1 (NDRG1).
9/2016	The novel thiosemicarbazone, di-2-pyridylketone 4-cyclohexyl-4-methyl-3-thiosemicarbazone (DpC), inhibits neuroblastoma growth in vitro and in vivo via multiple mechanisms.
5/2016	Targeting the Metastasis Suppressor, N-Myc Downstream Regulated Gene-1, with Novel Di-2-Pyridylketone Thiosemicarbazones: Suppression of Tumor Cell Migration and Cell-Collagen Adhesion by Inhibiting Focal Adhesion Kinase/Paxillin Signaling.

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Zaklina Kovacevic Research Topics

Disease

45	Neoplasms (Cancer) 01/2021 - 12/2006
31	Neoplasm Metastasis (Metastasis) 01/2021 - 12/2006
7	Pancreatic Neoplasms (Pancreatic Cancer) 01/2019 - 10/2008
5	Prostatic Neoplasms (Prostate Cancer) 01/2020 - 01/2009
4	Hypoxia (Hypoxemia) 01/2020 - 05/2012
3	Breast Neoplasms (Breast Cancer) 01/2021 - 03/2018
2	Carcinogenesis 10/2020 - 01/2017
2	Melanoma (Melanoma, Malignant) 03/2018 - 04/2016
2	Colonic Neoplasms (Colon Cancer) 05/2016 - 07/2014
1	Inflammation (Inflammations) 01/2017
1	Neuroblastoma 09/2016
1	Ataxia (Dyssynergia) 01/2016
1	Friedreich Ataxia (Friedreich's Ataxia) 01/2016
1	Alzheimer Disease (Alzheimer's Disease) 01/2016
1	Colorectal Neoplasms (Colorectal Cancer) 10/2015
1	Carcinoma (Carcinomatosis) 01/2013

Drug/Important Bio-Agent (IBA)

26	IronIBA 01/2020 - 12/2006
19	ThiosemicarbazonesIBA 10/2020 - 01/2011
17	Chelating AgentsIBA 01/2019 - 12/2006
12	di- 2- pyridylketone- 4,4- dimethyl- 3- thiosemicarbazoneIBA 10/2020 - 01/2013
9	Proteins (Proteins, Gene)FDA Link 01/2020 - 10/2008
8	CopperIBA 10/2019 - 01/2013
7	Antineoplastic Agents (Antineoplastics)IBA 01/2019 - 12/2006
6	MetalsIBA 01/2020 - 01/2015
5	di-2-pyridylketone 4- cyclohexyl- 4- methyl- 3- thiosemicarbazoneIBA 01/2017 - 10/2011
4	ErbB Receptors (EGF Receptor)IBA 08/2019 - 01/2016
4	CateninsIBA 01/2019 - 09/2013
4	LigandsIBA 08/2015 - 01/2011
3	Progesterone Receptors (Progesterone Receptor)IBA 01/2021 - 01/2016
3	NF-kappa B (NF-kB)IBA 10/2019 - 01/2013
3	Phosphotransferases (Kinase)IBA 01/2019 - 09/2013
3	Deferoxamine (Desferal)FDA LinkGeneric 01/2015 - 09/2012
2	Gemcitabine FDA Link 01/2021 - 10/2011
2	AndrogensIBA 01/2020 - 12/2006
2	Nitric Oxide (Nitrogen Monoxide)FDA Link 01/2020 - 12/2016
2	IonsIBA 01/2020 - 01/2017
2	MitogensIBA 08/2019 - 01/2019
2	Transforming Growth Factors (Transforming Growth Factor)IBA 01/2019 - 07/2014
2	Cyclin-Dependent Kinase Inhibitor p21IBA 01/2019 - 10/2011
2	tyrosine receptor (receptor, tyrosine)IBA 01/2019 - 11/2015
2	Cadherins (E-Cadherin)IBA 01/2019 - 07/2014
2	Messenger RNA (mRNA)IBA 03/2018 - 10/2015
2	EnzymesIBA 01/2017 - 04/2014
2	Reactive Oxygen Species (Oxygen Radicals)IBA 07/2016 - 04/2014
2	Proto-Oncogene Proteins c-akt (Protein Kinase B)IBA 01/2016 - 10/2015
2	Cyclin D1IBA 10/2015 - 10/2011
2	Pharmaceutical PreparationsIBA 10/2015 - 01/2013
2	DNA (Deoxyribonucleic Acid)IBA 10/2015 - 04/2014
2	Ribonucleotide Reductases (Ribonucleotide Reductase)IBA 10/2015 - 04/2014
2	Transforming Growth Factor beta (TGF-beta)IBA 01/2013 - 01/2009
1	LipidsIBA 01/2021
1	Insulin-Like PeptidesIBA 01/2021
1	Insulin-Like Growth Factor I (IGF-1)IBA 01/2021
1	Hepatocyte Growth Factor (Growth Factor, Hepatocyte)IBA 01/2021
1	Androgen Receptors (Androgen Receptor)IBA 01/2020
1	Free RadicalsIBA 01/2020
1	Tamoxifen FDA LinkGeneric 01/2020
1	enzalutamideIBA 01/2020
1	Estrogen ReceptorsIBA 01/2020
1	Glyoxal (Ethanedial)IBA 10/2019
1	Diacetyl (Biacetyl)IBA 10/2019
1	Protein Isoforms (Isoforms)IBA 01/2019
1	Iron Chelating AgentsIBA 01/2019
1	Tumor Necrosis Factor-alpha (Tumor Necrosis Factor)IBA 01/2017
1	dithiolIBA 12/2016
1	Glutathione Transferase (Glutathione S-Transferase)IBA 12/2016
1	multidrug resistance-associated protein 1IBA 12/2016
1	Member 1 Subfamily B ATP Binding Cassette TransporterIBA 12/2016
1	Biological ProductsIBA 12/2016
1	Progesterone FDA LinkGeneric 12/2016
1	Annexin A5IBA 09/2016
1	CaspasesIBA 09/2016
1	CholesterolIBA 07/2016
1	3- beta- (2- (diethylamino)ethoxy)androst- 5- en- 17- oneIBA 07/2016
1	CollagenIBA 05/2016
1	Focal Adhesion Protein-Tyrosine KinasesIBA 05/2016
1	PaxillinIBA 05/2016
1	Neoplasm Antigens (Tumor Antigens)IBA 04/2016
1	human ERBB2 proteinIBA 01/2016
1	Ferritins (Ferritin)IBA 01/2016
1	Transferrin (beta 2 Transferrin)IBA 01/2016
1	FrataxinIBA 01/2016
1	Calcium-Calmodulin-Dependent Protein KinasesIBA 01/2016
1	Protein-Tyrosine Kinases (Tyrosine Kinase)IBA 11/2015
1	IntegrinsIBA 11/2015
1	Cytoplasmic and Nuclear Receptors (Nuclear Receptors)IBA 11/2015
1	HydrazonesIBA 10/2015
1	Cyclin-Dependent Kinases (cdk Proteins)IBA 10/2015
1	Phosphatidylinositol 3-Kinase (1 Phosphatidylinositol 3 Kinase)IBA 10/2015
1	STAT3 Transcription Factor (Signal Transducer and Activator of Transcription 3)IBA 01/2015
1	InterleukinsIBA 01/2015
1	3-aminopyridine-2-carboxaldehyde thiosemicarbazone (triapine)IBA 04/2014
1	Mitogen-Activated Protein Kinase Kinases (MEKs)IBA 09/2013
1	Actins (F Actin)IBA 09/2013
1	TOR Serine-Threonine KinasesIBA 09/2013
1	Extracellular Signal-Regulated MAP Kinases (Extracellular Signal Regulated Kinases)IBA 09/2013
1	Poly(ADP-ribose) Polymerases (Poly ADP Ribose Polymerase)IBA 01/2013
1	Caspase 3 (Caspase-3)IBA 01/2013

Therapy/Procedure

15	Therapeutics 01/2020 - 01/2011
2	Drug Therapy (Chemotherapy) 01/2021 - 11/2013